p63 Antibody | F53705-0.1ML

p63 Antibody | F53705-0.1ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In ascites with 0.09% sodium azide

Format: Ascites

Clone: 603CT12.4.3

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, ELISA

Buffer: N/A

Limitation: This p63 antibody is available for research use only.

Purity: Ascites

Description: This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Immunogen: A portion of amino acids 651-680 from the human protein was used as the immunogen for this p63 antibody.

Storage: Aliquot the p63 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.