P53 Monoclonal Antibody | E-AB-22015

P53 Monoclonal Antibody | E-AB-22015 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human

Host: Mouse

Isotype: IgG

Application: WB, IHC-p, IF

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Background: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic Peptide

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification: Protein A purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:200

Conjugation: Unconjugated

Calculated Molecular Weight: 44 kDa

Observed Molecular Weight: 53 kDa

Clonality: Monoclonal