OX40 Antibody / CD134 | V8349-20UG

OX40 Antibody / CD134 | V8349-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: OX-86

Host Animal: Rat

Clonality: Monoclonal (rat origin)

Species Reactivity: Mouse

Application: FACS, IF

Buffer: N/A

Limitation: This CD134 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: CD134 is a type I integral membrane protein. This receptor is expressed on activated CD4+and CD8+T cells and B cells. The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th)1 and Th2 cells. CD134 is also involved in the stimulation of T cells, T dependent humoral response and generation of optimal CD4+ T cell responses in vivo and in vitro. CD134 is expressed on activated CD4+ T lymphocytes, and its ligand, CD134L, is found preferentially on activated B cells. Engagement of CD134 with its ligand, CD134L, delivers a strong costimulatory signal to effector T cells.

Immunogen: Purified recombinant mouse OX40 antigen was used as the immunogen for the CD134 antibody.

Storage: Store the CD134 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).