NMNAT1 Antibody / Nicotinamide-nucleotide adenylyltransferase 1 | F53836-0.2ML

NMNAT1 Antibody / Nicotinamide-nucleotide adenylyltransferase 1 | F53836-0.2ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB

Buffer: N/A

Limitation: This NMNAT1 antibody is available for research use only.

Purity: Antigen affinity

Description: Nicotinamide mononucleotide adenylyltransferase 1 catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.

Immunogen: A portion of amino acids 171-201 from the human protein was used as the immunogen for the NMNAT1 antibody.

Storage: Aliquot the NMNAT1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.