Description
Nav1.8/β2 - HEK293 Cell Line | 60521 | Gentaur US, UK & Europe Disrtribition
Category: Recombinant Cell Line/Ion Channel
Application: Drug compound screening. Functional assays. Efficient antigen for mouse immunization
Background: Nav1.8 is a voltage gated type X, alpha subunit sodium channel which in humans is encoded by the SCN10A gene. It is expressed in nociceptors and has been proposed as a target for the development of new analgesics. Mice deficient in Nav1.8 have deficits in sensing inflammatory pain (initiated by tissue damage/inflammation) and visceral pain (initiated by damage or injury to internal organs) but not neuropathic pain. Native sodium channels are complexes composed of the pore-forming α subunit and an auxiliary β subunit. The sodium channel β2 subunit, encoded by the SCN2B gene, increases current amplitude and surface expression of sodium ion channels.
Description: Stable recombinant HEK293 cell line expressing tetracycline-inducible human Nav1.8 (Genbank #NP_006505.2) fused to Green Fluorescent Protein (GFP) [Ex. ~395 nm, 475 nm; em ~510 nm] and C-terminal Streptavidin-Binding Peptide (SBP)-tag, and the human sodium channel β2 subunit (Genbank #NM_004588; SCN2B) with C-terminal FLAG-tag. Nav1.8 is also known as tetrodotoxin-resistant voltage-gated sodium channel type X (SCN10A).
Product Type: Cell Line
Shippement Condition: -80°C
