Description
NaV1.7-HEK293 Cell Line | 60507 | Gentaur US, UK & Europe Disrtribition
Category: Recombinant Cell Line/Ion Channel
Application: • Screen for activators or inhibitors of Nav1.7
• Functional assays for Nav1.7
• Efficient antigen for mouse immunization
Background: Nav1.7 is a voltage-gated sodium ion channel that in humans is encoded by the SCN9A gene. It is usually expressed at high levels in two types of neurons, the nociceptive neurons at dorsal root ganglion and trigeminal ganglion, and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system. Nav1.7 is present at the endings of pain-sensing nerves, the nociceptors, close to the region where the impulse is initiated.The Nav1.7 channel produces a rapidly activating and inactivating current which is sensitive to the level of tetrodotoxin. Knockout mice that lack Nav1.7 in nociceptors showed reduced response to inflammatory pain.
Description: Stable recombinant HEK293 cell line expressing human Nav1.7 (Genbank # Q15858) fused at the C-terminus to Green Fluorescent Protein [Ex. ~395 nm, 475 nm; em ~510 nm] and with Cterminal Streptavidin-Binding Peptide (SBP) fusion. Nav1.7 is a tetrodotoxin-sensitive voltagegated sodium channel type IX subunit alpha (SCN9A).
Product Type: Cell Line
Shippement Condition: -80°C
