N-Cadherin Antibody / CDH2 | V9199-20UG

N-Cadherin Antibody / CDH2 | V9199-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: MNCD2

Host Animal: Rat

Clonality: Monoclonal (rat origin)

Species Reactivity: Human, Mouse

Application: IHC-P

Buffer: N/A

Limitation: This CD325 antibody is available for research use only.

Purity: Protein A/G affinity

Description: Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

Immunogen: A portion of amino acids 308-597 was used as the immunogen for the CD325 antibody.

Storage: Aliquot the CD325 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.