MYH7 Polyclonal Antibody | E-AB-62836

MYH7 Polyclonal Antibody | E-AB-62836 | Gentaur US, UK & Europe Disrtribition

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Application: WB, IHC, IF

Research Area: Cancer, Cardiovascular, Developmental Biology, Signal Transduction, Stem Cells

Background: Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human MYH7 (NP_000248.2).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification: Affinity purification

Dilution: WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:200

Conjugation: Unconjugated

Calculated Molecular Weight: 223 kDa

Observed Molecular Weight: 223 kDa

Clonality: N/A