Myc Reporter (Luc) - HCT116 Cell Line (Myc Signaling Pathway) | 60520

Myc Reporter (Luc) - HCT116 Cell Line (Myc Signaling Pathway) | 60520 | Gentaur US, UK & Europe Disrtribition

Category: Cell Signaling/Cell Line

Application: Monitor Myc pathway activity and screen for activators or inhibitors of the Myc pathway.

Background: The Myc signaling pathway plays an important role in cell proliferation, differentiation, transformation and apoptosis. The c-Myc protein is a transcription factor that heterodimerizes with Max to regulate transcription of genes involved in proliferation, transformation and angiogenesis. Myc mutations have been linked to the development of a number of human cancers, including Burkitt's lymphoma, cervical, ovarian, breast, lung and pancreatic carcinoma, making Myc a promising therapeutic target.

Description: The Myc Reporter - HCT116 cell line contains the firefly luciferase gene under the control of Myc responsive elements stably integrated into HCT116 cells, a human colon cancer cell line. HCT116 contains a mutated
beta-catenin which leads to the accumulation of β
-catenin and constitutive activation of downstream Myc that induces the expression of Myc luciferase reporter. The cell line is validated for the inhibition of the expression of Myc luciferase reporter.

Product Type: Cell Line

Shippement Condition: -80°C