MutL Protein Homolog 1(MLH1) Monoclonal Antibody | PA6124

MutL Protein Homolog 1(MLH1) Monoclonal Antibody | PA6124 | Gentaur US, UK & Europe Disrtribition

Clone : YN01116m

Reactivity : Human

Application : IHC-P

Host : Mouse

Category : RTU for IHC

Concentration : 100μg/mL for the RTU antibody, 1mg/mL for the concentrated antibody

Buffer : TBS with 0.1% Proclin300, PH7.4

Backgound : MutL Protein Homolog 1(MLH1) is a mismatch repair gene, which is located on p-arm 21.3 of chromosome 3. And DNA mismatch repair is very necessary to maintain the integrity of genetic information. The change of microsatellite reproducibility is caused by the slippage of the hinge misalignment during DNA replication, also known as microsatellite instability. The defects of these DNA repair pathways are related to some human tumors. The mutant mismatch repair gene is often expressed in patients with high frequency microsatellite instability (MSI-H), which is related to autosomal dominant genetic diseases.