Mouse TNF-alpha Protein, Fc Tag, active trimer (MALS verified) | TNA-M5257-1mg

Mouse TNF-alpha Protein, Fc Tag, active trimer (MALS verified) | TNA-M5257-1mg| Gentaur Distribution US, UK & Europe

Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

Source: Mouse TNF-alpha Protein, Fc Tag (TNA-M5257) is expressed from human 293 cells (HEK293). It contains AA Leu 80 - Leu 235 (Accession # P06804-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Leu 80 - Leu 235.

Conjugate: Unconjugated.

Molecular Weight: 43.7 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 43.7 kDa. The protein migrates as 45-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT