MBP Antibody / Myelin Basic Protein | V8679-100UG

MBP Antibody / Myelin Basic Protein | V8679-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: MBP/4275

Host Animal: Rat

Clonality: Monoclonal (rat origin)

Species Reactivity: Human

Application: WB, IHC-P

Buffer: N/A

Limitation: This Myelin Basic Protein antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. MBP/4275 is used in clinical diagnostics to detect MBP levels or myelination in human MBP. MBP/4275 is used in a two-site ELISA with clone MBP/4273. Both are used interchangeably as capture and detection antibody.

Immunogen: N/A

Storage: Store the Myelin Basic Protein antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).