Human Progranulin Protein, His Tag, low endotoxin (MALS & SPR verified) | PGN-H52H3-1mg

Human Progranulin Protein, His Tag, low endotoxin (MALS & SPR verified) | PGN-H52H3-1mg| Gentaur Distribution US, UK & Europe

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene. Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 cysteine granulin motif. Many cellular processes and diseases are associated with this unique pleiotropic factor that include, but are not limited to, embryogenesis, tumorigenesis, inflammation, wound repair, neurodegeneration and lysosome function. Haploinsufficiency caused by autosomal dominant mutations within the GRN gene leads to frontotemporal lobar degeneration, a progressive neuronal atrophy that presents in patients as frontotemporal dementia.

Source: Human Progranulin Protein, His Tag (PGN-H52H3) is expressed from human 293 cells (HEK293). It contains AA Thr 18 - Leu 593 (Accession # P28799-1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Thr 18 - Leu 593.

Conjugate: Unconjugated.

Molecular Weight: 63.7 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 63.7 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT