Human LILRB4 / CD85k / ILT3 Protein, Mouse IgG2a Fc Tag (MALS verified) | LI4-H5257-1mg

Human LILRB4 / CD85k / ILT3 Protein, Mouse IgG2a Fc Tag (MALS verified) | LI4-H5257-1mg| Gentaur Distribution US, UK & Europe

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Source: Human LILRB4, Mouse IgG2a Fc Tag (LI4-H5257) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Glu 259 (Accession # AAH26309.1).

Format: Powder.

Tag: C-mFc (mIgG2a).

Expression System: HEK293.

Expression Region: Gln 22 - Glu 259.

Conjugate: Unconjugated.

Molecular Weight: 53.3 kDa.

Characteristics: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 53.3 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT