Description
Human LIGHT / TNFSF14 Protein, Fc Tag, active trimer (MALS verified) | LIT-H5269-100ug| Gentaur Distribution US, UK & Europe
Tumor necrosis factor ligand superfamily member 14 (LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
Source: Human LIGHT Protein, Fc Tag (LIT-H5269) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1) trimer Design.
Format: Powder.
Tag: N-Fc.
Expression System: HEK293.
Expression Region: Asp 74 - Val 240.
Conjugate: Unconjugated.
Molecular Weight: 82.6 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 82.6 kDa. The protein migrates as 116 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
