Human Latent TGF-beta 3 / Latent TGFB3 Protein, His Tag | TG3-H52H5-1mg

Human Latent TGF-beta 3 / Latent TGFB3 Protein, His Tag | TG3-H52H5-1mg| Gentaur Distribution US, UK & Europe

Transforming growth factor beta 3 ( TGFB3) is also known as TGF-β3, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. TGF-beta 3 is similar with TGF-beta 1 and ­-beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial­-mesenchymal transition. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.

Source: Human Latent TGF-beta 3, His Tag (TG3-H52H5) is expressed from human 293 cells (HEK293). It contains AA Leu 24 - Ser 412 (Accession # P10600-1).

Format: Powder.

Tag: N-10×His.

Expression System: HEK293.

Expression Region: Leu 24 - Ser 412.

Conjugate: Unconjugated.

Molecular Weight: 46.8 kDa.

Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 46.8 kDa. The protein migrates as 44-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT