Human ICOS / CD278 (C136S, C137S) Protein, His Tag (MALS verified) | ICS-H52H9-1mg

Human ICOS / CD278 (C136S, C137S) Protein, His Tag (MALS verified) | ICS-H52H9-1mg| Gentaur Distribution US, UK & Europe

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Source: Human ICOS (C136S, C137S), His Tag (ICS-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Phe 141 (Accession # NP_036224.1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Glu 21 - Phe 141.

Conjugate: Unconjugated.

Molecular Weight: 15.7 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 26-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT