Human FcRn / FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (MALS & SPR verified) | FCM-H5283-50ug

Human FcRn / FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (MALS & SPR verified) | FCM-H5283-50ug| Gentaur Distribution US, UK & Europe

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

Source: Human FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (FCM-H5283) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # P55899-1 (FCGRT) & P61769-1 (B2M) ).

Format: Powder.

Tag: C-Twin-Strep | Native.

Expression System: HEK293.

Expression Region: Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M).

Conjugate: Unconjugated.

Molecular Weight: 33.8 kDa (FCGRT) & 11.7 kDa (B2M).

Characteristics: Human FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free, produced by co-expression of FCGRT and B2M, has a calculated MW of 33.8 kDa (FCGRT) and 11.7 kDa (B2M). Subunit FCGRT is fused with Strep II-tag at the C-terminus and subunit Beta-2 microglobulin (B2M) contains no tag. The reducing (R) protein migrates as 12 kDa (FCGRT) and 38-45 kDa (B2M) respectively due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT