Human ALPL Protein, His Tag (active enzyme, MALS verified) | ALL-H52H3-1mg

Human ALPL Protein, His Tag (active enzyme, MALS verified) | ALL-H52H3-1mg| Gentaur Distribution US, UK & Europe

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.

Source: Human ALPL Protein, His Tag (ALL-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 18 - Ser 502 (Accession # P05186-1).

Format: Liquid.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Leu 18 - Ser 502.

Conjugate: Unconjugated.

Molecular Weight: 55.3 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.3 kDa. The protein migrates as 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 20 mM Tris, 150 mM NaCl, 20% Glycerol, pH7.5.

Storage Conditions: -70℃.

Shipping Conditions: Dry ice