GPRC5D Lentivirus | 78716

GPRC5D Lentivirus | 78716 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Lentivirus

Application: Generate stable cell line expressing human GPRC5D with hygromycin selection

Background: G protein-coupled receptor class C group 5 member D (GPRC5D) is an orphan receptor of little-known function belonging to the large family of G protein-coupled receptors. The protein is highly expressed in malignant plasma cells such multiple myeloma and is now considered a therapeutic target for antibody-based treatment of multiple myeloma. For example, CAR T cells and GPCR5DxCD3 bispecific antibodies are under development.

Description: The GPRC5D Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human GPRC5D (NM_018654.1) driven by a CMV promoter and a Hygromycin selection marker (Figure 1). Figure 1: Schematic of the lenti-vector used to generate the GPRC5D Lentivirus

Product Type: Lentivirus

Shippement Condition: -80°C