Description
GPRC5D HEK293 Cell Line | 78345 | Gentaur US, UK & Europe Disrtribition
Category: CAR-T/Cell Line
Application: 1. Human GPRC5D binding assays; screen for GPRC5D ligands or antibodies.
2. Target cells for anti-GPRC5D CAR-T development.
Background: The orphan G protein-coupled receptor, class C group 5 member D (GPRC5D) is a retinoic acid-inducible protein with seven transmembrane segments and a short N-terminal extracellular region. The strong and selective expression of GPRC5D in Multiple Myeloma cells, similar to the expression pattern of B-cell maturation antigen (BCMA), makes it a promising target for the treatment of Multiple Myeloma. It is anticipated that GPRC5D will be an alternative CAR T cell target for Multiple Myeloma immunotherapy.
Description: Recombinant HEK293 cells constitutively expressing human GPRC5D (the orphan G protein-coupled receptor, class C group 5 member D, NM_018654.1) under the control of a CMV promoter.
Product Type: Cell Line
Shippement Condition: -80°C
