GBL Antibody | N1215-25UG

GBL Antibody | N1215-25UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB

Buffer: 1X PBS, pH 7.4

Limitation: This GBL antibody is available for research use only.

Purity: Protein A affinity chromatography

Description: GBL (G protein beta subunit-like), also called MLST8 (MTOR associated protein, LST8 homolog), is a subunit of the mTOR signaling complexes mTORC1 and mTORC2, which help regulate cell growth and survival in response to growth factor (mTORC1 & 2) and nutrient (mTORC1) signaling. It is required for the phosphorylation of S6 kinase and the signal adaptor protein Insulin receptor substrate 1 and S473 phosphorylation of AKT. GBL is also a regulator of TNFa-induced NF-kB activity, with overexpression inhibiting and down-regulation enhancing NF-kB signaling (Kim et al, 2008).

Immunogen: A recombinant protein fragment from the internal region of human GBL was used as the immunogen for this antibody.

Storage: Aliquot the GBL antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.