FcGRIIB (CD32B) Lentivirus | 79877

FcGRIIB (CD32B) Lentivirus | 79877 | Gentaur US, UK & Europe Disrtribition

Category: Cell Line/Lentiviruses

Application: 1. Transient expression of FcGRIIB in target cells.
2. Generation of stable cell line expressing FcGRIIB with Geneticin (G418) selection.

Background: N/A

Description: Fc Gamma Receptor 2B (FcGR2B, FcγRIIB), also known as CD32B, is a "low affinity" receptor for Immunoglobulin G (IgG). FcGR2B is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. It is the predominant Fc receptor present on B cells. Crosslinking of antibodies by FcGR-expression cells can promote receptor clustering and increase downstream signaling. FcGR2B crosslinking is important for anti-TNFR receptor antibodies.
The FcGRIIB Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types mammalian cells, including primary and non-dividing cells. The particles contain a FcGRIIB gene (NM_004001.4) driven by a CMV promoter.

Product Type: Lentivirus

Shippement Condition: -80°C