DMBT1 Polyclonal Antibody | E-AB-40467

DMBT1 Polyclonal Antibody | E-AB-40467 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Application: IHC

Research Area: Signal Transduction

Background: Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.

Lead Time: 7~10 days

Concentration: 0.71mg/mL

Storage: Store at -20℃. Avoid freeze / thaw cycles.

Immunogen: Recombinant Human Deleted in malignant brain tumors 1 protein

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.

Purification: Antigen Affinity Purification

Dilution: IHC 1:200-1:500

Conjugation: Unconjugated

Calculated Molecular Weight: N/A

Observed Molecular Weight: N/A

Clonality: Polyclonal