Decanoyl-RVKR-CMK | 78713-3

Decanoyl-RVKR-CMK | 78713-3 | Gentaur US, UK & Europe Disrtribition

Category: Coronavirus/Substrate

Application: Inhibition of furin and related endoprotease/proprotein convertase (PC1, PC2, PC4, PACE4, PC5, PC7). Useful as control inhibitor when using the Furin Protease Assay Kit (BPS Bioscience #78040). Useful when studying the role of Furin in viral fusion with BPS Bioscience Spike pseudoviruses or ACE2-HEK cell lines.

Background: N/A

Description: Decanoyl-Arg-Val-Lys-Arg-chlororomethylketone, also called Subtilisin/Kex2p-like proprotein convertase inhibitor, is a small, synthetic, irreversible and cell-permeable modified RVKR peptide that inhibits the seven pro-protein convertases: furin and PC1, PC2, PC4, PACE4, PC5, PC7.
Proprotein convertases cleave proproteins to generate bioactive peptides or to activate enzymes and growth factors, thus regulating critical biological processes and playing a role in pathologies such as cancer or viral infection. Therefore, they represent potential therapeutic targets in a number of diseases.
As an inhibitor of furin, Decanoyl-RVKR-CMK blocks the fusion of flavaviruses and coronaviruses, including SARS-CoV-2, with the membrane of human host cells. It also inhibits the processing of

Product Type: Substrate

Shippement Condition: -20°C