Cytokeratin 14 Antibody / CK14 / KRT14 | V4062-20UG

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SKU:
800-V4062-20UG
Size:
20 ug
€649.00
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Description

Cytokeratin 14 Antibody / CK14 / KRT14 | V4062-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: KRT14/4127

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This Keratin 14 antibody is available for research use only.

Purity: Protein A/G affinity

Description: Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.

Immunogen: A portion of amino acids 351-472 from the human KRT14 protein was used as the immunogen for the Keratin 14 antibody.

Storage: Aliquot the Keratin 14 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

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