Cynomolgus TNFSF11 / RANKL / CD254 Protein, His Tag, active trimer (MALS verified) | RAL-C5243-1mg

Cynomolgus TNFSF11 / RANKL / CD254 Protein, His Tag, active trimer (MALS verified) | RAL-C5243-1mg| Gentaur Distribution US, UK & Europe

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.

Source: Cynomolgus TNFSF11 Protein, His Tag (RAL-C5243) is expressed from human 293 cells (HEK293). It contains AA Gly 136 - Asp 317 (Accession # A0A7N9DBU4).

Format: Powder.

Tag: N-10×His.

Expression System: HEK293.

Expression Region: Gly 136 - Asp 317.

Conjugate: Unconjugated.

Molecular Weight: 22.4 kDa.

Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 22.4 kDa. The protein migrates as 30-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT