Cynomolgus MMP-9 Protein, His Tag (active enzyme) | MM9-C52H3-50ug

Cynomolgus MMP-9 Protein, His Tag (active enzyme) | MM9-C52H3-50ug| Gentaur Distribution US, UK & Europe

Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.

Source: Cynomolgus MMP-9 Protein, His Tag (MM9-C52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 469 (Accession # XP_005569271.2). It needs to be activated by agents such as APMA in vitro to have hydrolytic activity.

Format: Liquid.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Ala 20 - Pro 469.

Conjugate: Unconjugated.

Molecular Weight: 51.8 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 51.8 kDa. The protein migrates as 65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: 25 mM Tris, 150 mM NaCl, pH7.5.

Storage Conditions: -70℃.

Shipping Conditions: Dry ice