Cynomolgus KLRG1 Protein, Fc Tag (SPR verified) | KL1-C5269-100ug

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SKU:
716-KL1-C5269-100ug
Availability:
IN STOCK
Size:
100 ug
€520.00
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Description

Cynomolgus KLRG1 Protein, Fc Tag (SPR verified) | KL1-C5269-100ug| Gentaur Distribution US, UK & Europe

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.

Source: Cynomolgus KLRG1 Protein, Fc Tag (KL1-C5269) is expressed from human 293 cells (HEK293). It contains AA Leu 60 - Pro 189 (Accession # A0A2K5WAP9).

Format: Powder.

Tag: N-Fc.

Expression System: HEK293.

Expression Region: Leu 60 - Pro 189.

Conjugate: Unconjugated.

Molecular Weight: 41.3 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 41.3 kDa. The protein migrates as 43-53 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Argine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT

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