Cynomolgus Coagulation factor XI Protein, His Tag (SPR verified) | FXI-C52H3-50ug

Cynomolgus Coagulation factor XI Protein, His Tag (SPR verified) | FXI-C52H3-50ug| Gentaur Distribution US, UK & Europe

This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

Source: Cynomolgus Coagulation factor XI, His Tag (FXI-C52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 19 - Ala 624 (Accession # G7MSF8-1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Glu 19 - Ala 624.

Conjugate: Unconjugated.

Molecular Weight: 69.8 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 69.8 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: 20 mM HEPES, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT