Cyclin D1 Antibody / CCND1 | V2830PE-100T

Cyclin D1 Antibody / CCND1 | V2830PE-100T | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: PE Conjugate

Clone: SPM587

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: FACS

Buffer: N/A

Limitation: This Cyclin D1 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Immunogen: Human recombinant full length protein was used as the immunogen for the Cyclin D1 antibody.

Storage: Store the Cyclin D1 antibody at 2-8oC. Conjugate is light sensitive, store in the dark.