Description
CXCR1 Antibody | R31191 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, FACS
Buffer: Lyophilized from 1X PBS with 2% Trehalose
Limitation: This CXCR1 antibody is available for research use only.
Purity: Antigen affinity
Description: Chemokine CXC Motif Receptor 1, also known as IL8R, is the receptor for IL8. Morris et al.(1992) mapped the gene to chromosome 2q35. Hartl et al.(2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Binding of IL-8 to its receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. CXCR1 binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
Immunogen: An amino acid sequence from the N-terminus of human Chemokine CXC Motif Receptor 1 (DEDYSPCMLETETLN) was used as the immunogen for this CXCR1 antibody.
Storage: After reconstitution, the CXCR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.