Description
CTLA4 / IL-2 Reporter - Jurkat Recombinant Cell Line | 79525 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: • Screen for activators or inhibitors of CTLA4 signaling in a cellular context
• Characterize the biological activity of CTLA4 and its interactions with ligands
Background: CTLA4, also known as CD152, is a protein receptor that functioning as an immune checkpoint. It is expressed by activated T cells and transmits an inhibitory signal to T cells. CTLA4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells. CTLA-4 binds to CD80 and CD86 with greater affinity and avidity than CD28 thus enabling it to outcompete CD28 for its ligands and act as an "off" switch when bound to CD80 or CD86. CTLA-4 is an important immunotherapy target for the treatment of cancer and autoimmune diseases.
Description: Recombinant Jurkat T cell expressing firefly luciferase gene under the control of IL-2 promoter with constitutive expression of human CTLA4 (Cytotoxic T-Lymphocyte Associated Protein, CD152; GenBank Accession #NM_005214).
Product Type: Cell line
Shippement Condition: -80°C
