Description
Claudin-9 Lentivirus | 78721 | Gentaur US, UK & Europe Disrtribition
Category: Cell Signaling/Lentivirus
Application: Generate stable cell line expressing human Claudin-9 with puromycin selection
Background: Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-9 is one of the 27 members of the Claudin family. Claudin-9 is overexpressed in hepatocellular carcinoma, where it enhances the metastatic potential of hepatocytes via Tyk2/Stat3 signaling. Claudin-9 is also a marker for endometrial cancer, and acts as a receptor for Clostridium perfringens enterotoxin (CPE) during infection by gram-positive Clostridial bacteria. C. perfringens infection causes for food poisoning and gastrointestinal illnesses, via Claudin-9 to toxin-induced gut barrier breakdown.
Description: The Claudin-9 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human Claudin-9 (NM_020982) driven by an EF1A promoter and a puromycin selection marker (Figure 1).
Figure 1: Schematic of the lenti-vector used to generate the Claudin-9 Lentivirus.
Product Type: Lentivirus
Shippement Condition: -80°C
