Description
CEACAM5 Lentivirus | 78719 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Lentivirus
Application: Generate a stable cell line expressing human CEACAM5 with puromycin selection
Background: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5, also known as CD66e) is a cell surface glycoprotein that serves as a cell adhesion protein. It has been used as a clinical biomarker to detect liver metastasis from gastrointestinal cancers and to predict gastrointestinal cancer relapse. CEACAM5 was recently identified as a potential target antigen for CAR T-cell therapy. Additionally, CEACAM5 may be involved in the inhibition of cell differentiation, apoptosis, and cell polarity.
Description: The CEACAM5 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human CEACAM5 (NM_004363.6) driven by an EF1A promoter and a puromycin selection marker (Figure 1).
Figure 1: Schematic of the lenti-vector used to generate the CEACAM5 Lentivirus
Product Type: Lentivirus
Shippement Condition: -80°C