CD244 Antibody | R31168

CD244 Antibody | R31168 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IHC-P

Buffer: N/A

Limitation: This CD244 antibody is available for research use only.

Purity: Antigen affinity

Description: Cluster of Differentiation 244 is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4. Tangye et al.(1999) mapped the gene to 1q22. Suzuki et al.(2008) identified a functional single-nucleotide polymorphism(SNP) in the gene that contributes to rheumatoid arthritis susceptibility. Functional analysis by Boles et al.(1999) demonstrated that engagement of CD244 with specific antibody activates NK cytolytic activity. Using recombinant human NK cell-activating ligand CD244 fused to domains 3 and 4 of rodent Cd4 and flow cytometric analysis, Brown et al.(1998) demonstrated that CD48 binds to CD244. Watzl et al.(2000) showed that antibody-mediated cross-linking of the protein leads to its rapid tyrosine phosphorylation, which is necessary for CD244-mediated killer cell activity.

Immunogen: An amino acid sequence from the C-terminus of human Cluster of Differentiation 244 (RLSRKELENFDVYS) was used as the immunogen for this CD244 antibody.

Storage: After reconstitution, the CD244 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.