CD137 Antibody / 4-1BB / TNFRSF9 | V8353SAF-100UG

CD137 Antibody / 4-1BB / TNFRSF9 | V8353SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: LOB12

Host Animal: Rat

Clonality: Monoclonal (rat origin)

Species Reactivity: Mouse

Application: Functional Studies, FACS, IF

Buffer: N/A

Limitation: This CD137 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.

Immunogen: A murine CD137 human Fc fusion protein was used as the immunogen for the CD137 antibody.

Storage: Store the CD137 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).