Biotinylated Human Insulin R / CD220 (28-944) Protein, His, Avitag™ (MALS & SPR verified) | INR-H82E6-25ug

Biotinylated Human Insulin R / CD220 (28-944) Protein, His, Avitag™ (MALS & SPR verified) | INR-H82E6-25ug| Gentaur Distribution US, UK & Europe

Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.

Source: Biotinylated Human Insulin R (28-944) Protein, His, Avitag (INR-H82E6) is expressed from human 293 cells (HEK293). It contains AA His 28 - Lys 944 (Accession # P06213-2).

Format: Powder.

Tag: C-10×His & C-Avi.

Expression System: HEK293.

Expression Region: His 28 - Lys 944.

Conjugate: Biotin-labeled.

Molecular Weight: 108.2 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 108.2 kDa. The protein migrates as 115-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT