Description
Biotinylated Human IL-23 alpha&IL-12 beta Heterodimer Protein, His, Avitag™&Tag Free (MALS verified) | ILB-H82W6-25ug| Gentaur Distribution US, UK & Europe
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Source: Biotinylated Human IL-23 alpha&IL-12 beta Heterodimer Protein, His, Avitag&Tag Free (ILB-H82W6) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (IL23A) & Ile 23 - Ser 328 (IL12B) (Accession # Q9NPF7-1 (IL23A) & P29460-1 (IL12B) ).
Format: Powder.
Tag: N-10×His & N-Avi | Native.
Expression System: HEK293.
Expression Region: Arg 20 - Pro 189 (IL23A) & Ile 23 - Ser 328 (IL12B).
Conjugate: Biotin-labeled.
Molecular Weight: 21.9 kDa (IL23A) & 34.7 kDa (IL12B).
Characteristics: Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His, Avitag&Tag Free, produced by co-expression of IL23A and IL12B, has a calculated MW of 21.9 kDa (IL23A) & 34.7 kDa (IL12B). Subunit IL23A is fused with an Avi tag (Avitag™), followed by a polyhistidine tag at the N-terminus and subunit IL12B contains no tag. The predicted N-terminus is His (IL23A) & Ile 23 (IL12B). The reducing (R) protein migrates as 26 kDa (IL23A) & 40-45 kDa (IL12B) respectively due to glycosylation.
Purity: 95%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
