Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein (Monomer, MALS verified) | HLP-H82Eb-25ug

Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein (Monomer, MALS verified) | HLP-H82Eb-25ug| Gentaur Distribution US, UK & Europe

TP53 has been recognized as a tumor suppressor. 50% of cancers carry a TP53 mutation while many others affect other pathway components. High-copy numbers of WT p53 peptide-MHC class I complexes were detected on tumor cells as compared to low copies on normal cells. The Human HLA-A*0201 p53 (GLAPPQHLIRV) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and GLAPPQHLIRV peptide of the p53.

Source: Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein (HLP-H82Eb) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 305 (HLA-A*24:02) & Ile 21 - Met 119 (B2M) & TYSPALNKMF peptide (Accession # AAA59600.1 (HLA-A*24:02) & P61769 (B2M) TYSPALNKMF).

Format: Powder.

Tag: C-10×His & C-Avi.

Expression System: HEK293.

Expression Region: Gly 25 - Ile 305 (HLA-A*24:02) & Ile 21 - Met 119 (B2M) & TYSPALNKMF peptide.

Conjugate: Biotin-labeled.

Molecular Weight: 35.8 kDa and 11.7 kDa.

Characteristics: Biotinylated Human HLA-A*24:02&B2M&p53 (TYSPALNKMF) Complex Protein is produced by co-expression of HLA and B2M loaded with p53 peptide. This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 35.8 kDa and 11.7 kDa. The protein migrates as 39-42 kDa and 10 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT