BAX Polyclonal Antibody | E-AB-40495

BAX Polyclonal Antibody | E-AB-40495 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Application: WB, IHC-P

Research Area: Cancer, Cell Biology, Metabolism

Background: BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction . BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria . The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis .

Lead Time: 7~10 days

Concentration: 0.566mg/mL

Storage: Store at -20℃. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of Human Apoptosis regulator BAX

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.

Purification: Antigen Affinity Purification

Dilution: WB 1:1000-1:3000, IHC 1:50-1:200

Conjugation: Unconjugated

Calculated Molecular Weight: 21 kDa

Observed Molecular Weight: 21 kDa

Clonality: Polyclonal