B7-H4 Lentivirus | 78727

B7-H4 Lentivirus | 78727 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Lentivirus

Application: Generate a stable cell line expressing human B7-H4 with puromycin selection

Background: B7-H4, also known as V-set domain-containing T-cell activation inhibitor 1 (VTCN1), is an immune checkpoint protein found on the surface of antigen-presenting cells. Its receptor has not yet been identified, but B7-H4 binds to receptor(s) on the surface of T cells, inhibiting T cell responses and suppressing tumor-associated immunity. High expression levels of B7-H4 have been correlated with tumor progression, particularly in ovarian and breast cancer.

Description: The B7-H4 Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human B7-H4 (NM_ 024626.4) driven by a CMV promoter and a puromycin selection marker (Figure 1). Figure 1: Schematic of the lenti-vector used to generate the B7-H4 Lentivirus.

Product Type: Lentivirus

Shippement Condition: -80°C