B7-H4 CHO Cell Line-78586-M | 78586-M

B7-H4 CHO Cell Line-78586-M | 78586-M | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Cell Line

Application: • Screen and validate antibodies against B7-H4 for drug discovery and research • Screen for compounds or ligands that regulate or inhibit B7-H4 signaling in a cellular context • Optimize and perform biological assays

Background: B7-H4 is an immune checkpoint that belongs to the B7 family and is encoded by the VTCN1 gene. B7-H4 is expressed on the surface of antigen presenting cells, interacting with currently unidentified ligands to negatively regulate immune cell responses and suppress tumor-associated immunity. B7-H4 also contributes to changes in the tumor microenvironment that benefit cancer cells and support their proliferation, survival, invasion, and metastasis. B7-H4 is highly expressed in some cancer cells, and has been correlated with tumor progression, particularly in ovarian and breast cancer, making it an attractive target for immunotherapy. 

Description: B7-H4 CHO Cell line is a recombinant clonal stable CHO-K1 cell line constitutively expressing full length human B7-H4 protein, also known as V-set domain-containing T-cell activation inhibitor 1 (VTCN1); (NM_024626.4). Surface expression of B7-H4 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of B7-H4 expression (Medium and High), to mimic different B7-H4 expression levels in various cancer types.

Product Type: Cell Line

Shippement Condition: -80°C