Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) (Trehalose free) | S1N-M12A1-100mg

Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) (Trehalose free) | S1N-M12A1-100mg| Gentaur Distribution US, UK & Europe

It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Source: AntiN/ASARSN/ACoVN/A2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM122) is a chimeric monoclonal antibody recombinantly expressed from HEK293 cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARSN/ACoVN/A2 Spike S1 protein. As verified in competitive ELISAN/Abased and pseudovirusN/Abased neutralization assay,  this chimeric monoclonal can potently neutralize all SARSN/ACoVN/A2 Variants of Concern (VOCs), including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2)  .

Molecule: Spike RBD.

Species: Mouse.

Tag: Human IgG1 | Human Kappa.

Conjugate: Unconjugated.

Purity: 95%.

Charactirization: PBS, pH7.4.

Storage Conditions: -70℃.

Shipping Conditions: Dry ice