Alexa Fluor™ 488-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining | GUC-HA2H5-25ug

Alexa Fluor™ 488-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His TagStar Staining | GUC-HA2H5-25ug| Gentaur Distribution US, UK & Europe

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

Source: Alexa Fluor 488-Labeled Human GUCY2C Protein, His Tag (GUC-HA2H5) is produced via conjugation of AF488 to Human GUCY2C Protein, His Tag with a new generation site-specific technology under Star Staining labeling platform. Human GUCY2C Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Ser 24 - Gln 430.

Conjugate: AF488 Labeled.

Molecular Weight: 62.6 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 62.6 kDa.

Purity: N/A.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃, aviod light.

Shipping Conditions: RT