AIFM1 Polyclonal Antibody | E-AB-40255

AIFM1 Polyclonal Antibody | E-AB-40255 | Gentaur US, UK & Europe Disrtribition

Reactivity: Rat

Host: Rabbit

Isotype: IgG

Application: WB

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism

Background: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Rat Apoptosis-inducing factor 1, mitochondrial protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification: Antigen Affinity Purification

Dilution: WB 1:500-1:1000

Conjugation: Unconjugated

Calculated Molecular Weight: 67 kDa

Observed Molecular Weight: 67 kDa

Clonality: Polyclonal