AGO3 Antibody / Argonaute-3 / eIF2C3 | V9391SAF-100UG

AGO3 Antibody / Argonaute-3 / eIF2C3 | V9391SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: PCRP-AGO3-1C5

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA, FACS, IF

Buffer: N/A

Limitation: This AGO3 antibody is available for research use only.

Purity: Protein A/G affinity

Description: This antigen is involved in binding and translation repression of short RNAs. This antigen is also known as Argonaute RISC catalytic component 3. Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5-flanking sequences to the region of guide-target complementarity.

Immunogen: Recombinant full-length human AGO3 protein was used as the immunogen for the AGO3 antibody.

Storage: Aliquot the AGO3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.