AF488 Anti-Mouse CD8a Antibody | DL21268F-4

AF488 Anti-Mouse CD8a Antibody | DL21268F-4 | Gentaur US, UK & Europe Disrtribition

Synonyms: T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL

Reactivity: Mouse

Host: Rat

Application: FCM

Background: CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α (CD8a) /β (CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

Concentration: 0.5 mg/mL

Conjugation: AF488

Buffer: PBS with 0.05% Proclin300, 1% BSA

Isotype: Rat IgG2a, κ

Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.