AF/LE Purified Anti-Human CD279/PD-1 Antibody | DL21621F-3

AF/LE Purified Anti-Human CD279/PD-1 Antibody | DL21621F-3 | Gentaur US, UK & Europe Disrtribition

Synonyms: PD-1, Programmed Death-1

Reactivity: Human

Host: Mouse

Application: Block,Neut,FCM

Background: Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Concentration: 0.5 mg/mL

Conjugation: None (Purified antibody-Azide Free/Low endotoxin)

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Isotype: Mouse IgG1, κ

Storage: Store at 2~8°C. Do not freeze.