A2M Antibody / Alpha-2-Macroglobulin | V8506SAF-100UG

A2M Antibody / Alpha-2-Macroglobulin | V8506SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: A2M/3621

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This Alpha-2-Macroglobulin antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Alpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.

Immunogen: A portion of amino acids 604-748 from the human protein was used as the immunogen for the Alpha-2-Macroglobulin antibody.

Storage: Store the Alpha-2-Macroglobulin antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).